Fertility window that isn't properly regulated in some women may be associated with increased risk of miscarriage that these women face.
A new study conducted by researchers from Warwick Medical School, shows how the length and timing of the fertility window in women can affect their chances of a miscarriage.
In the uterus, cytokine IL-33 is released and its cell receptor (ST2) is activated. This leads to inflammatory response that regulates the stage known as peak fertility. This window lasts for two or three days.
Study showed that women who had many failed pregnancies had inflammatory responses that were too long. When the fertility window remains open for long, the embryos are implanted in an environment that doesn't support pregnancy, leading to miscarriage.
Researchers explained why this study is so important in understanding miscarriages.
"The study fundamentally changes our understanding of the issue with far reaching clinical implications. The IL-33/ST2 pathway is already considered to be a major target for therapeutic interventions across Alzheimer's, cardiovascular disease, obesity, asthma and other autoimmune disorders. We believe that targeting the same pathway in the uterus may help to prevent miscarriage by regulating the fertility window," said Professor Siobhan Quenby of the Division of Reproductive Health, who along with Jan Brosens led the study.
"It's an exciting discovery that we hope will mean new developments for a group of women for who there isn't currently any help," Quenby added.