George W. Bush, the one-time 43nd President of the United States, will be remembered for a myriad of accomplishments and failures during his time in office.

One notable, if rarely acknowledged, victory was his administration's push to secure funding for public health initiatives to fight back against HIV in Africa. In 2003, Bush directly funneled $15 million over five years through the President’s Emergency Plan for AIDS Relief (PEPFAR) to help in the prevention, treatment and research of HIV/AIDS — an agenda that has continued to this day. By the time Bush left office, the program contributed to the treatment of 2 million people living with HIV, the care of 10 million people, and the prevention of HIV from mother to child in 16 million pregnancies.

Now, in an upcoming special this December 1st, VICE on HBO will discuss the continuing success of the PEPFAR program and George Bush’s legacy against HIV as part of its overarching report of the future of the viral disease. Betraying its sense of grandeur, the aforementioned “Countdown To Zero” will ask the provocative question of whether the end of the road has finally arrived for HIV, sending its intrepid reporters to the various corners of the world where breakthroughs in research have been emerging from.

Along the way, as seen in the clip above, correspondent Shane Smith will interview Bush about the PEPFAR program, while Suroosh Alvi will connect with U2 singer and unlikely Bush fan, Bono, as they travel to Rwanda to see the lasting effects of PEPFAR on the nation’s children.

It’s sure to be an informative and possibly uplifting time.