Array ( [a_id] => 291608 [c_id] => 14 [r_id] => 700 [rr_id] => 700 [m_id] => 1 [s_id] => 25646 [id_id] => 0 [v_id] => 0 [loc_id] => 0 [ft_id] => 0 [a_classification] => news [a_layout] => 1 [a_headline] => Freezing Testicular Tissue May Save Sperm From Young Boys Undergoing Cancer Treatment [a_sheadline] => Freezing Testicular Tissue May Save Young Cancer Survivors' Sexual Futures [a_slug] => freezing-testicular-tissue-may-save-sperm-young-boys-undergoing-cancer-treatment-291608 [a_subheadline] => [a_summary] => In an effort to avoid sexual side effects of cancer treatment on young boys, scientists have begun developing a way to preserve their healthy sperm — by freezing parts of their testicles. [a_article] =>
Being diagnosed with cancer is never easy for a child or his family. Advanced therapeutics have greatly increased survival rates but there are still several side effects that can occur years after treatment. For boys, these side effects may affect their sexual development, rendering them unable to have children. While sperm banking is an option for older boys, young boys who haven't yet reached puberty must find other options. A new study has found one such option, finding that young boys may be able to freeze a part of their testicular tissue so that it can be defrosted years later to generate sperm cells.
The method, which was developed by scientists at Yokohama City University, Japan, was used on mice. In their study, published in the journal Nature Communications, the scientists reported about how they were able to produce sperm from frozen testicular tissue and grow baby mice. Now, they're trying to develop the same technique for humans, albeit with several roadblocks. For example, human tissue requires a different lab setup.
The scientists have so far been unsuccessful in regenerating human sperm from frozen testicle tissue. “We have to optimize the culture conditions in each species," said lead author Takehiko Ogawa, a urologist and scientist at the university's Graduate School of Medicine, according to USA Today. But they're optimistic about the potential of their findings.
Richard Yu, a pediatric urologist with Dana-Farber/Boston Children's Cancer and Blood Disorders Center in Boston, told USA Today that the research is promising, saying that he'd preserve his son's testicular tissue if he ended up with cancer. "Research in the last few years really is encouraging that the technique will be available in the future," he told USA Today. "The alternative is to do nothing and your child has a high risk of sterility."
Both radiation and chemotherapy damage cells in the testicles affecting sperm production, according to the American Cancer Society. These effects can occur even if the therapy is aimed in an area other than the groin, such as the head, where the pituitary gland is responsible for secreting sexual hormones. High doses of certain chemotherapy drugs may also have the same affect.
If the technique becomes possible for humans, it would be a good precatuinary measure for any boy undergoing cancer treatment, as side effects tend to be unpredictable, with some boys experiencing temporary effects and others more permanent ones. Though death rates have gone down significantly over the past few years, follow-up care is essential for helping these children get back to normalcy. As part of a larger effort to reduce the side effects of childhood cancer care, strategies like Ogawa's may be one step in that direction.
Source: Ogawa T, Yokonishi T, Sato T, et al. Offspring production with sperm grown in vitrofrom cryopreserved testis tissues. Nature Communications. 2014.
[a_keyword] => Frozen mice testicle tissue used to develop babies. Gives hope to cancer survivors. [a_wordcount] => 482 [a_note] => [a_published] => 1 [a_updated] => 0 [a_writtenTime] => 2014-07-07 11:26:52 [a_submittedTime] => 2014-07-07 11:26:52 [a_modifiedTime] => 2014-07-07 11:26:51 [a_publishedTime] => 2014-07-07 11:26:52 [a_editor] => 1 [a_closeComment] => 1 [a_level] => 3 [a_social] => Freezing Testicular Tissue May Save Sperm From Young Boys Undergoing Cancer Treatment [a_commission] => 0 [a_countDown] => [a_countDownText] => [link] => https://www.medicaldaily.com/freezing-testicular-tissue-may-save-sperm-young-boys-undergoing-cancer-treatment-291608 [categories] => Array ( [0] => Array ( [c_id] => 14 ) ) [real] => Array ( [ar_id] => 11698 [a_id] => 291608 [r_id] => 700 [ar_num] => 0 [ar_prefix] => [ar_suffix] => [ar_show] => 1 [ar_weight] => 0 [ar_replace] => [id_id] => 0 [r_img_show] => 0 [r_name] => Shweta Iyer [r_slug] => reporters/shweta-iyer [r_title] => [r_prefix] => [r_suffix] => [r_type] => [r_desc] => [r_email] => s.iyer@medicaldaily.com [r_facebook] => [r_twitter] => [r_linkedin] => [r_country] => [r_team] => 0 [r_nef] => [r_company] => [r_article_count] => 261 [r_aid] => 0 [r_parent_id] => 0 [r_allow] => 1 [r_active] => 0 [cen_r_id] => 0 [r_time] => 2014-05-21 16:35:33 [temp_id] => 0 ) [reporters] => Array ( [0] => Array ( [ar_id] => 11698 [a_id] => 291608 [r_id] => 700 [ar_num] => 0 [ar_prefix] => [ar_suffix] => [ar_show] => 1 [ar_weight] => 0 [ar_replace] => [id_id] => 0 [r_img_show] => 0 [r_name] => Shweta Iyer [r_slug] => reporters/shweta-iyer [r_title] => [r_prefix] => [r_suffix] => [r_type] => [r_desc] => [r_email] => s.iyer@medicaldaily.com [r_facebook] => [r_twitter] => [r_linkedin] => [r_country] => [r_team] => 0 [r_nef] => [r_company] => [r_article_count] => 261 [r_aid] => 0 [r_parent_id] => 0 [r_allow] => 1 [r_active] => 0 [cen_r_id] => 0 [r_time] => 2014-05-21 16:35:33 [temp_id] => 0 ) ) [reporterAll] => Array ( [0] => Array ( [r_id] => 700 [r_name] => Shweta Iyer [r_team] => 0 [r_slug] => reporters/shweta-iyer [ar_weight] => 0 ) ) [reviews] => Array ( ) [s_name] => Medical Daily [s_slug] => medical-daily [s_credit] => Published by Medicaldaily.com [web_id] => 0 [s_aid] => 0 [cen_s_id] => 0 [s_url] => [s_order] => 0 [s_photo] => [s_allow] => 1 [a_facebook] => 0 [a_twitter] => 0 [a_plus] => 0 [a_linkedin] => 0 [a_reddit] => 0 [a_views] => 2 [r_headline] => Freezing Testicular Tissue May Save Young Cancer Survivors' Sexual Futures [a_error] => 0 [a_search] => Freezing Testicular Tissue May Save Sperm From Young Boys Undergoing Cancer Treatment [a_h1] => [a_standout] => 0 [a_standouted] => 0 [a_special] => [a_rshare] => 0 [a_applenews_id] => [a_applenews_revision] => [a_url_slug] => [a_noindex] => 0 [a_link] => [a_syndication] => 1 [a_meta_description] => [a_key_points] => [a_tier] => [a_value1] => [a_value2] => 0 [a_weight] => 0 [a_whitelist] => 1 [a_permanant_whitelist] => 0 [a_parent_id] => 0 [a_web_id] => 0 [a_rank] => 0 [a_ads] => 1 [a_google_ai] => 0 [a_disclaimer] => 1 [a_cloudsearch] => 0 [a_json] => [keywords] => Array ( [0] => Array ( [k_id] => 1675 [k_keyword] => Cancer [k_page_title] => [k_meta_description] => Cancer is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the bod [k_slug] => cancer [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Cancer is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumors are cancerous. Benign tumors do not grow uncontrollably, do not invade neighboring tissues, and do not spread throughout the body. [k_tree] => 1675 [k_parent_id] => 0 [k_ancestry] => -1675- [k_level] => 0 [k_article] => [k_allow] => 2 [k_time] => 2015-10-09 17:14:17 [k_photo] => [k_tid] => 26545 [k_tslug] => conditions/cancer [k_approved] => 0 ) [1] => Array ( [k_id] => 1682 [k_keyword] => Sexual health [k_page_title] => [k_meta_description] => Sexual health is a state of physical, emotional, mental and social well-being in relation to sexuality; it is not merely the absence of disease, dysfunction or infirmity. Sexual health requires a positive and respectful approach to sexuality and sexual re [k_slug] => sexual-health [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Sexual health is a state of physical, emotional, mental and social well-being in relation to sexuality; it is not merely the absence of disease, dysfunction or infirmity. Sexual health requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence. [k_tree] => 1682 [k_parent_id] => 0 [k_ancestry] => -1682- [k_level] => 0 [k_article] => [k_allow] => 2 [k_time] => 2015-08-17 20:38:50 [k_photo] => [k_tid] => 26673 [k_tslug] => conditions/sexual-health [k_approved] => 0 ) [2] => Array ( [k_id] => 3554 [k_keyword] => Men's health [k_page_title] => [k_meta_description] => Men's health refers to health issues specific to human male anatomy. These often relate to structures such as male genitalia or to conditions caused by hormones specific to, or most notable in, males. [k_slug] => mens-health [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Men's health refers to health issues specific to human male anatomy. These often relate to structures such as male genitalia or to conditions caused by hormones specific to, or most notable in, males. [k_tree] => 3554 [k_parent_id] => 0 [k_ancestry] => -3554- [k_level] => 0 [k_article] => 1342 [k_allow] => 2 [k_time] => 2015-02-24 10:23:50 [k_photo] => [k_tid] => 26590 [k_tslug] => conditions/mens-health [k_approved] => 0 ) [3] => Array ( [k_id] => 5856 [k_keyword] => Pediatric Diseases [k_page_title] => [k_meta_description] => Pediatrics (or paediatrics) is the branch of medicine that deals with the medical care of infants, children, and adolescents. [k_slug] => pediatric-diseases [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Pediatrics (or paediatrics) is the branch of medicine that deals with the medical care of infants, children, and adolescents. [k_tree] => 5856 [k_parent_id] => 0 [k_ancestry] => -5856- [k_level] => 0 [k_article] => [k_allow] => 2 [k_time] => 2017-09-20 12:30:15 [k_photo] => [k_tid] => 26667 [k_tslug] => conditions/pediatrics [k_approved] => 0 ) [4] => Array ( [k_id] => 21515 [k_keyword] => Frozen mice testicle tissue used to develop babies. Gives hope to cancer survivors. [k_page_title] => [k_meta_description] => [k_slug] => frozen-mice-testicle-tissue-used-to-develop-babies-gives-hope-to-cancer-survivors [k_type] => 0 [id_id] => [file_id] => [c_id] => 0 [m_id] => 1 [k_text] => [k_tree] => 21515 [k_parent_id] => 0 [k_ancestry] => -21515- [k_level] => 0 [k_article] => [k_allow] => 1 [k_time] => 2014-07-07 11:26:52 [k_photo] => [k_tid] => 0 [k_tslug] => [k_approved] => 0 ) ) [shorten] => [locations] => Array ( ) [related] => Array ( ) [channels] => Array ( ) [graphic] => Array ( ) [feature] => Array ( ) [topics] => Array ( [0] => Array ( [k_id] => 1675 [k_keyword] => Cancer [k_page_title] => [k_meta_description] => Cancer is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the bod [k_slug] => cancer [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Cancer is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumors are cancerous. Benign tumors do not grow uncontrollably, do not invade neighboring tissues, and do not spread throughout the body. [k_tree] => 1675 [k_parent_id] => 0 [k_ancestry] => -1675- [k_level] => 0 [k_article] => [k_allow] => 2 [k_time] => 2015-10-09 17:14:17 [k_photo] => [k_tid] => 26545 [k_tslug] => conditions/cancer [k_approved] => 0 [k_count] => 1703 ) [1] => Array ( [k_id] => 1682 [k_keyword] => Sexual health [k_page_title] => [k_meta_description] => Sexual health is a state of physical, emotional, mental and social well-being in relation to sexuality; it is not merely the absence of disease, dysfunction or infirmity. Sexual health requires a positive and respectful approach to sexuality and sexual re [k_slug] => sexual-health [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Sexual health is a state of physical, emotional, mental and social well-being in relation to sexuality; it is not merely the absence of disease, dysfunction or infirmity. Sexual health requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence. [k_tree] => 1682 [k_parent_id] => 0 [k_ancestry] => -1682- [k_level] => 0 [k_article] => [k_allow] => 2 [k_time] => 2015-08-17 20:38:50 [k_photo] => [k_tid] => 26673 [k_tslug] => conditions/sexual-health [k_approved] => 0 [k_count] => 1036 ) [2] => Array ( [k_id] => 3554 [k_keyword] => Men's health [k_page_title] => [k_meta_description] => Men's health refers to health issues specific to human male anatomy. These often relate to structures such as male genitalia or to conditions caused by hormones specific to, or most notable in, males. [k_slug] => mens-health [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Men's health refers to health issues specific to human male anatomy. These often relate to structures such as male genitalia or to conditions caused by hormones specific to, or most notable in, males. [k_tree] => 3554 [k_parent_id] => 0 [k_ancestry] => -3554- [k_level] => 0 [k_article] => 1342 [k_allow] => 2 [k_time] => 2015-02-24 10:23:50 [k_photo] => [k_tid] => 26590 [k_tslug] => conditions/mens-health [k_approved] => 0 [k_count] => 1273 ) [3] => Array ( [k_id] => 5856 [k_keyword] => Pediatric Diseases [k_page_title] => [k_meta_description] => Pediatrics (or paediatrics) is the branch of medicine that deals with the medical care of infants, children, and adolescents. [k_slug] => pediatric-diseases [k_type] => 0 [id_id] => [file_id] => 0 [c_id] => 0 [m_id] => 1 [k_text] => Pediatrics (or paediatrics) is the branch of medicine that deals with the medical care of infants, children, and adolescents. [k_tree] => 5856 [k_parent_id] => 0 [k_ancestry] => -5856- [k_level] => 0 [k_article] => [k_allow] => 2 [k_time] => 2017-09-20 12:30:15 [k_photo] => [k_tid] => 26667 [k_tslug] => conditions/pediatrics [k_approved] => 0 [k_count] => 999 ) ) [first_info] => Array ( [eh_id] => 26536 [eh_what] => article [a_id] => 291608 [eh_type] => imageBox [eh_align] => block [eh_width] => 736 [eh_height] => [eh_w] => 736 [eh_h] => 0 [eh_position] => -2 [eh_text] => [eh_parent] => 0 [eh_num] => 0 [eh_time] => 2014-07-07 11:26:52 [eh_x1] => 291644 [eh_d1] => 291644 [eh_d2] => [eh_d3] => In an effort to avoid sexual side effects of cancer treatment on young boys, scientists have begun developing a way to preserve their healthy sperm — by freezing parts of their testicles. [eh_d4] => [eh_d5] => Frozen [eh_d6] => [eh_d7] => [eh_d8] => [eh_d9] => [eh_d10] => [eh_d11] => ) [review_item] => Array ( ) [a_content_first] => [a_content] =>Being diagnosed with cancer is never easy for a child or his family. Advanced therapeutics have greatly increased survival rates but there are still several side effects that can occur years after treatment. For boys, these side effects may affect their sexual development, rendering them unable to have children. While sperm banking is an option for older boys, young boys who haven't yet reached puberty must find other options. A new study has found one such option, finding that young boys may be able to freeze a part of their testicular tissue so that it can be defrosted years later to generate sperm cells.
The method, which was developed by scientists at Yokohama City University, Japan, was used on mice. In their study, published in the journal Nature Communications, the scientists reported about how they were able to produce sperm from frozen testicular tissue and grow baby mice. Now, they're trying to develop the same technique for humans, albeit with several roadblocks. For example, human tissue requires a different lab setup.
The scientists have so far been unsuccessful in regenerating human sperm from frozen testicle tissue. “We have to optimize the culture conditions in each species," said lead author Takehiko Ogawa, a urologist and scientist at the university's Graduate School of Medicine, according to USA Today. But they're optimistic about the potential of their findings.
Richard Yu, a pediatric urologist with Dana-Farber/Boston Children's Cancer and Blood Disorders Center in Boston, told USA Today that the research is promising, saying that he'd preserve his son's testicular tissue if he ended up with cancer. "Research in the last few years really is encouraging that the technique will be available in the future," he told USA Today. "The alternative is to do nothing and your child has a high risk of sterility."
Both radiation and chemotherapy damage cells in the testicles affecting sperm production, according to the American Cancer Society. These effects can occur even if the therapy is aimed in an area other than the groin, such as the head, where the pituitary gland is responsible for secreting sexual hormones. High doses of certain chemotherapy drugs may also have the same affect.
If the technique becomes possible for humans, it would be a good precatuinary measure for any boy undergoing cancer treatment, as side effects tend to be unpredictable, with some boys experiencing temporary effects and others more permanent ones. Though death rates have gone down significantly over the past few years, follow-up care is essential for helping these children get back to normalcy. As part of a larger effort to reduce the side effects of childhood cancer care, strategies like Ogawa's may be one step in that direction.
Source: Ogawa T, Yokonishi T, Sato T, et al. Offspring production with sperm grown in vitrofrom cryopreserved testis tissues. Nature Communications. 2014.
[a_content_last] => [a_aside] => [a_content_first_type] => imageBox [a_content_last_type] => [a_content_embed] => [reps] => Array ( [0] => Shweta Iyer ) [repid] => Array ( [0] => 700 ) [image] => Array ( [id_id] => 291644 [id_name] => Frozen [id_caption] => In an effort to avoid sexual side effects of cancer treatment on young boys, scientists have begun developing a way to preserve their healthy sperm — by freezing parts of their testicles. [id_short_caption] => [id_credit] => Photo courtesy of Shutterstock [id_keyword] => [id_gallery] => [id_adult] => 0 [id_hide] => 0 [id_source] => [id_photographer] => [id_text] => [id_ext] => jpg [id_location] => [id_width] => 1000 [id_height] => 667 [id_left] => 50 [id_top] => 40 [id_quality] => 85 [id_filesize] => 56136 [s_id] => [m_id] => 61 [x_id] => 0 [id_time] => 2014-07-07 11:24:39 [id_submittedTime] => 2014-07-07 11:24:39 [id_url] => [id_published] => 1 [img_name] => public://2014/07/07/frozen.jpg [ori] => https://d.medicaldaily.com/en/full/291644/frozen.jpg [src] => https://d.medicaldaily.com/en/full/291644/frozen.jpg [tag] => src="https://d.medicaldaily.com/en/full/291644/frozen.jpg" alt="Frozen " [picture] =>