Vitality

Heart Disease Risk Rises With Testosterone Levels; How A Man’s Hormones Change His Heart Health

Heart Disease Risk Men
A man's heart disease risk could be determined by his testosterone level. Photo courtesy of Shutterstock

Heart disease is one of the greatest killers in America, and high testosterone levels may be what puts men at risk. Those were the findings from a new study out of Harvard, and could lead to a new risk factor for heart disease in men. The results were presented at ENDO 2015, the 97th annual meeting of the Endocrine Society.

"These observations may help explain why men have a higher risk of cardiovascular disease," said the study’s lead researcher Dr. Elaine Yu, a professor at Harvard Medical School, in a press release. Yu and her team studied the testosterone levels of 400 men between the ages of 20 and 50, and compared them to their cholesterol levels in order to figure out whether testosterone had any effect on their risk of heart disease.

Each man received the drug gosereline to suppress his own testosterone and estrogen levels. Then, half of them received either a placebo or one of four doses of testosterone gel — some of which brought their testosterone levels down to what they were before puberty. The other half of the participants also received a drug called anatrozole, which blocked testosterone's conversion to estrogen, thus making their estrogen levels especially low. 

The higher a man’s testosterone level was, the lower their “good” cholesterol levels dropped. The drugs seemed to have no effect on “bad” cholesterol levels (low-density lipoprotein cholesterol). The female hormone estrogen, which is in both men and women, had no effect on the men's risk, however, it did lead to worsening insulin resistance and the accumulation of more fat in muscle.

Cardiovascular disease (CVD) is the leading cause of death for both men and women, according to the American Heart Association, however, men are at a higher risk. More than one in three men have CVD, threatening over 8.8 million lives every day in America. Now that researchers know high testosterone levels may explain the differences in risk between men and women, they have an additional risk factor to work with. 

This isn’t the first time Harvard researchers have investigated the link between testosterone and heart health. One study, published in The Journal of the American Medical Association, involved 8,700 elderly male veterans, and found those who underwent testosterone therapy had a 30 percent higher risk of heart attack, stroke, and even death over a three-year period. They theorized testosterone might be boosting risk by encouraging the formation of dangerous blood clots.

Each year, an additional 350,000 men are diagnosed with heart failure, making it a prevailing health concern in America. One day sex hormone therapy may be used to lower testosterone and increase estrogen in order to regulate those in higher risk populations, such as those who are overweight or obese.

Source: Yu Elaine, et al. Endocrine Society's 97th annual meeting. 2015.

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