Innovation

Scientists Reverse Aging By Tightly Packing DNA Together In Cells

Maintaining youth and even immortality has been one of humanity’s fantasies since the beginning of time. In the modern age, scientists who study cellular aging have been trying to get to the bottom of what makes us grow old and eventually die — and if there is any way to turn that around. Now, a new study finds that reversing aging may be a matter of packing DNA together in cells to prevent it from unraveling.

The study, completed by an international group of researchers, concentrated on a gene that causes Werner syndrome — a disease that involves accelerated aging in young people, leaving them with osteoporosis, gray hair, and heart disease. Werner syndrome patients lack a specific gene that copies DNA and repairs any mistakes in it. The same gene also maintains telomeres, or the caps of DNA at the end of chromosomes that are associated with aging and health. People with Werner syndrome age quickly because of this lacking gene, but scientists weren’t quite sure how exactly this happened until now.

In the study, the researchers analyzed embryonic stem cells that had had the gene removed, and watched them age prematurely. The researchers noticed something fascinating: They aged so quickly because their DNA, which should be tightly wound together into something called heterochromatin, wasn’t being packaged properly. Instead, it was loosely wound and messy, which made the chromosomes unstable.

The researchers' take on the results? “It’s clear that when you have alterations in [chromosome stability], the process of aging goes so quickly and so fast that it’s tempting to say, yes, this is the key process for driving aging,” Izpisua Belmonte, an author of the study, said, according to Time. “What this study means is that this protein does not only work in a particular genetic disease, it works in all humans. This mechanism is general for aging process.”

Healthy cells vs. cells lacking gene Normal human cells, on the left, compared to cells lacking the gene responsible for chromosome stability on the right. Source: Salk Institute

Whether the researchers can use these results to develop anti-aging drugs, or completely reverse aging, is yet to be seen. All that we know for now is that “accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging,” Belmonte said in the press release, although there are plenty of other factors that go into the process of aging like telomere shortening.

This leaves the authors with plenty of questions: “Can we reverse these alterations — like remodeling an old house or car — to prevent, or even reverse, age-related declines and diseases[?]” Belmonte states. More research will be needed to better understand how scientists may one day fight aging by focusing on keeping heterochromatin tightly knit.

Source: Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. 2015.

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